methods, to achieve “euthanasia”, for rats and other laboratory animals are ongoing, as reflected in recent updates to the Canadian Council on Animal Care (CCAC) and American Veterinary Medical Association (AVMA) eu-thanasia guidelines [3, 4]. Materials. Approach-avoidance testing Approach-avoidance testing allows researchers to compare rats’ motivation for a reward against their motivation to avoid gas exposure. Agricultural Research; CCAC guidelines on : the care and use of farm animals in research, teaching and testing; Other resources. Daily Enrichment opportunities include features to promote activity, substrates for burrowing, structures to facilitate hiding or avoidance, objects to chew, variety in food, and foraging opportunities. This Standard Operating Procedure (SOP) describes the procedure of orally dosing rats and mice. Ethics of animal investigation (CCAC, 1989) Scientific merit and ethical review of animal-based research (CCAC, 2013) Terms of reference for animal care committees (CCAC, 2006) Assessment panels (CCAC, 2006) Ethical principles and guidelines for experiments on animals (Switzerland, 1995) Education & Training Education and Training (2014). Ninety percent of these are rats, mice, fish, and fowl. PURPOSE This Standard Operating Procedure (SOP) describes guidelines for the management of rat breeding colonies. DZn��*U@��g �eb�xɟ+_2012l ���Hs�?ç�� *CU emailE=('ccac@' + 'ccac.ca') h��V{lS�?��3Əkǐ�Iӛpq��[��AR�. (2011) National Research Council, USA In studies assessing rat aversion to euthanasia agents, These are the sources and citations used to research Chronic Restraint Stress in Rats. Agricultural Research; CCAC guidelines on : the care and use of farm animals in research, teaching and testing; Other resources. Paper towel. Email: %%EOF Experimental procedures involving the use of animals in this study were approved by the University Animal Care Committee (UACC) of Queen's University and complied with the guidelines of the Canadian Council of Animal Care (CCAC). Responsibility (1998) Canadian Council on Animal Care, Canada; Guide for the care and use of laboratory animals. Guidelines for the Survival Bleeding of Mice and Rats. CCAC resources. endstream endobj startxref RESPONSIBILITY Principal investigator (PI) and their research staff, animal care staff and veterinary care staff. who is responsible at the local level for ensuring that the CCAC guidelines and policies are followed? e����7+���ob��/~"p��/���b���9��_A3)Q���K����:{L7\'V6���Y�f.pH'b�.S��Iɻw�(�f��=@+]��j�1cm����z�p@��.wZ�S��|{�]��W��i�>ѣp���f���K� The CCAC conducts assessment visits to each participating institution using animals. // w\���{I���t�z>Ҭ��ԟB3�iCfP�W���[��$�,|�Щ��N����_��9������6:� �Y��c�~հp0���O�:a���w��ӠM,��Y^-I��oɿYU�+'w���#9�3�#yd߮w�����x�>��5}��������/�{ Y�)�f'�b T΍k ,��-��t�{8����\'L�V)�H)U=��l��}ߵ�8��Ǵ�v��s����w~�\� Zb zX�� ��g\H� @#DBZ�� h�D���] �9h� ^���9[CY?�|�b\�*AR��I�9x*! Rats spent an average of 47 s in cages filled with air. Ottawa, ON, K2P 2R3 2. Oral Dosing (Gavage) in Adult Mice and Rats SOP . When using oil or viscous gel adjuvant (e.g., FCA) in rabbits, mice or rats, SC is the recommended route. Guidelines for the use of animals in cancer research This is a selection of guidelines in the public domain that address the care and use of animals in cancer research, including the issue of … Policy: Laurentian University and CCAC guidelines and Regulations. The guidelines contained within the Guide to Care and Use of Experimental Animals, vol 1, 2nd edition (1993) are currently being revised. Intraperitoneal (IP) Injection in Rats and Mice SOP Page 2 of 4 Procedure 1. CCAC guidelines establish the basic requirements for each institutional program within the Canadian system of oversight of animal ethics and care. CCAC Guidelines: The current CCAC guidelines indicate that for cancer research the experiment must be designed with endpoints that minimize the potential for pain and/or distress. MATERIALS 3.1. Fax: 613-238-2837 Surveillance over the use of experimental animals, including wild vertebrates and invertebrates such as octopi and squid, is the responsibility of the Canadian Council on Animal Care (CCAC), a national, voluntary peer … �Z0:Bn�@q�-�^~�uX�OdcHކ��P?x�T�3i�//���.�kb����d{�$u�a&F�TLR�m8�{`e�Ǯ@]kX��!����[��t��`�z�H��˔���f� �`3��'��g���^�[��/��LI�z��F��2^�{�R���8��q�,�H[*��Spˌ�� ����Txw{�U5&�n��-e��5��6�]�΢���.���6���mv��m+���Y���[����=�$���a�e']R��X=/���BaQ��X���MxF!OCV��uOx�������G��x=I�J��Ęݧ����u�L�1�?�gd8\M��D1Y漶�s�d��9B�7o�X��7�B����0���.2,V�%R/�%y�UN���V�cBDUr}���޴�Y��!�Ӂ���^�[�]����:�w� �T%��N�S��=����9�{n�,��)�����۠ �{ֻ��Y�z��>�&^�6��3�y�;�Č51����^�����o��*��_ʱgˆ�Ǜg�ү�Uda�C��4:՚�x"����u*0��[� �USQ��}Y�����B�� �J�0?��Uc�����U�h廬}�Gx���e'&2������«�.���Xjrq�k �L 8%)�' 3. Responsibility: Technologists . 4146 0 obj <>/Filter/FlateDecode/ID[<90C47C91D84E48C49C31241C391AB876><55AB78EB64346C4BA606F51FF4F157B1>]/Index[4128 38]/Info 4127 0 R/Length 102/Prev 1528554/Root 4129 0 R/Size 4166/Type/XRef/W[1 3 1]>>stream Excellence in research is based on outstanding science and adherence to ethical, professional, and regulatory standards associated with the conduct of studies. The guidelines are based on expert peer advice and current interpretation of … endstream endobj 4129 0 obj <>/Metadata 377 0 R/Names 4147 0 R/OpenAction 4130 0 R/Outlines 867 0 R/PageLayout/OneColumn/Pages 4101 0 R/StructTreeRoot 1082 0 R/Type/Catalog/ViewerPreferences<>>> endobj 4130 0 obj <> endobj 4131 0 obj <. CCAC guidelines establish the basic requirements for each institutional program within the Canadian system of oversight of animal ethics and care. Biological effects of blood loss: implications for sampling volumes and techniques. 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